Thu. May 19th, 2022

Macrophage migration inhibitory factor (MIF) is a pleiotropic protein that regulates the innate immune response. MIF binds to its surface receptor CD74 and stimulates immune and inflammatory responses. MIF assembles itself in a trimeric composition, comprising three identical subunits. Further, each monomer consists of two antiparallel α-helices and a four-stranded β-sheet. Each monomer assembles around a central column in a 3-fold rotational symmetry. The MIF superfamily also has a functionally related member, D-dopachrome tautomerase.

Macrophage migration inhibitory factor (MIF) is an essential human pleiotropic protein that regulates the innate immune response. MIF binds to its surface receptor CD74, and stimulates immune and inflammatory responses. The human MIF gene on chromosome 22q11.23 encodes the MIF protein. The MIF protein assembles itself in a trimeric composition, comprising three identical subunits. Further, each monomer consists of two antiparallel α-helices and a four-stranded β-sheet. Each monomer assembles around a central column in a 3-fold rotational symmetry.

The human MIF gene on chromosome 22q11.23 encodes the MIF protein. The human MIF gene is 86,344 bases in length and the coding region is contained within 14 exons. MIF binds to its surface receptor CD74 and stimulates immune and inflammatory responses. MIF protein can be expressed in a variety tissues including blood cells, thymus, skin, testis, and pancreas.

Macrophage migration inhibitory factor (MIF) is an essential human pleiotropic protein that regulates the innate immune response. The human MIF gene on chromosome 22q11.23 encodes the MIF protein. MIF binds to its surface receptor CD74 and stimulates immune and inflammatory responses. The MIF protein assembles itself in a trimeric composition, comprising three identical subunits. Further, each monomer consists of two antiparallel α-helices and a four-stranded β-sheet. Each monomer assembles around a central column in a 3-fold rotational symmetry. The MIF superfamily also has a functionally related member, D-dopachrome tautomerase.

What is Interferon? Interferon beta (IFN B) or interferon type I is a human cytokine encoded by the IFNB1 gene. IFN B belongs to the Interferon type I family that regulates the immune system in humans. There are two subtypes of IFN B proteins: IFNB1 and IFNB3. IFN B binds to the IFN-α/β receptor, a cell surface receptor complex comprising two chains, IFNAR1 and IFNAR2. This receptor is present in the membranes of almost all cells.

If you are new to the world of medical acronyms, acronyms like MIF can be confusing and overwhelming. There are a number of great acronyms for which there is an abundant amount of information on, but there also others that can cause confusion in the healthcare setting. IFN B is an important acronym that stands for interferon-beta and represents a type of protein.

Interferon Beta (IFN β) is required for the transmission of some retroviruses. Retroviruses are viruses that contain RNA instead of DNA as their genetic material and usually have an enzyme (reverse transcriptase) that converts the RNA into DNA. These particular kinds of viruses are often found in animals known as vertebrates, but not viruses that infect other organisms. There are two major types of retrovirus: those that infect animals and those that infect plants. The interferon beta is implicated in fighting these viruses, or detoxifying them so they cannot survive or replicate themselves.

By Muhammad Hammad

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